Amazing Spider-Man #406 (1995)

"Crossroads," Written by J. M. DeMatteis, pencils by Angel Medina, inks by Larry Mahlstedt and Randy Emberlin.  Cover pencils by Mark Bagley, inks by Larry Mahlstedt.

Peter is worried that there is another time bomb buried somewhere in his psyche and goes to Seward Trainer for help. But the new Doctor Octopus has also set her sights on the good doctor, who has developed a stable interface between the real world and virtual reality.  She wants it, and she doesn’t care how many Spiders she must crush to get it!

Key book; first full appearance of Lady Octopus. Near mint condition.